The main block of the journal is formed from original articles in which qualified specialists in the history and philosophy of science and technology publish the results of their research. The contents of the journal are divided into the following main headings: "General Problems of the History of Natural Science and Technology", "From the History of Natural Science", "Social History of Science", "From the History of Technology", "History Lessons", "Historical Reviews", "Materials for the Biographies of Scientists and Engineers", "Institutes and Museums", "Sources for the History of Science and Technology", "Problems of Science Studies", reflecting the scope and specifics of the proposed scientific publications. The information block contains memoirs, reviews, reviews of new books, annotations of defended dissertations, as well as information about past conferences and correspondence with readers.